Patients who are sensitive to aspirin may also be sensitive to tartrazine, a yellow dye used in medicines and foods. Symptoms of an allergic reaction (urticaria, rhinitis, or asthma) may occur after exposure to many chemicals used to colour, flavour, or preserve food and drugs, but tartrazine (FD & C yellow No. 5) is the colour most frequently incriminated. Intolerance to tartrazine was first reported in 1959, and its part in induction of intractable urticaria has been recognised since 1975. Non-thrombocytopenic purpura is also reported to be due to hypersensitivity to tartrazine---which suggests the possibility that tartrazine may act as a hapten bound to the endothelial cells of small blood vessels.
Source: "Sensitivity to tartrazine" at
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1500754&blobtype=pdf
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Tartrazine-containing Drug Products Available in the Philippines*
Metronidazole (Pharex Metronidazole) 250 mg and 500 mg tablet
Mfr/Dist..: Pascual Lab., Inc./Pharex HealthCorp
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* If you know of a drug product containing tartrazine available in the Philippines, kindly inform the pinoypharmacist through your comment or by e-mail (pinoypharmacist@yahoo.com)
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