Studies in animals given polyethoxylated castor oil have shown a severe anaphylactic reaction associated with histamine release. Strong circumstantial evidence implicates polyethoxylated castor oil in similar reactions in humans. Polyethoxylated castor oil, when given to patients over a period of several days, can also produce abnormal lipoprotein electrophoretic patterns, alterations in blood viscosity and erythrocyte aggregation (red blood cell clumping).
___________Source: Vitamin K: A literature review by Karin Rothville DipCBEd (http://www.whale.to/a/rothville.html
Vitamin K product containing polyethoxylated castor oil as non-ionic surfactant:
Phytomenadione (Cycomin) 10 mg/mL Injection
Mfr./Distr.:Rotexmedica, GmbH/Duopharma Trade Phils., Inc.
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Note: If you know of any drug product containing polyethoxylated castor oil that is available in the Philippines, kindly e-mail at pinoypharmacist@yahoo.com. Your contribution will be highly appreciated.
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