Metoclopramide and paracetamol

"Metoclopramide increases gastric emptying and increases the absorption rate of paracetamol, an effect which is used to therapeutic advantage in the treatment of migraine."




Source: Clinical Pharmacy and Therapeutics, 4th ed. by Roger Walker and Cate Whittlesea

Digoxin and drugs that inhibit P-glycoprotein

"Digoxin is a substrate of P-glycoprotein and drugs that inhibit P-glycoprotein, such as verapamil, may increase digoxin bioavailability with the potential for digoxin toxicity (DuBuske 2005)."



Source:Clinical Pharmacy and Therapeutics, 4th ed. by Roger Walker and Cate Whittlesea

Bisphosphonates and calcium supplements

"Bisphosphonates are often co-prescribed with calcium supplements in the treatment of osteoporosis. If these are taken concomitantly, however, the bioavailability of both is significantly reduced, with the possibility of therapeutic failure."

Source: Clinical Pharmacy and Therapeutics, 4th ed. by Roger Walker and Cate Whittlesea, p. 42.

Simvastatin and grapefruit juice

"...[Patients] prescribed simvastatin should be advised not to drink grapefruit juice due to the increased risk of statin-induced adverse effects such as myopathy. Grapefruit juice inhibits cytochrome P450 3A4, which is involved in simvastatin's metabolism."

Source: Clinical Pharmacy and Therapeutics, 4th ed. by Roger Walker and Cate Whittlesea, p.40.

Weight gain and drugs for diabetes mellitus

"Unlike the sulfonylureas, insulin, and the thiazolidinediones, [alpha]-glucosidase inhibitors do not cause weight gain."



Source: Modern Pharmacology with Clinical Applications, 5th ed. by Charles R. Craig and Robert E. Stitzel, p. 775.

Mixing Insulin Glargine with other form of insulin

"Because it is necessary to maintain its acidic pH prior to injection, insulin glargine must not be mixed with any other form of insulin during injection."





Source: Modern Pharmacology with Clinical Applications, 5th ed. by Charles R. Craig and Robert E. Stitzel, p. 770.

Metformin and lactic acidosis

"Metformin can cause lactic acidosis, but its occurrence is rare except when renal failure, hypoxemia, or severe congestive heart failure is present or when coadministered with alcohol."

Source: Modern Pharmacology with Clinical Applications, 5th ed. by Charles R. Craig and Robert E. Stitzel, p. 773.