"...[Patients] prescribed simvastatin should be advised not to drink grapefruit juice due to the increased risk of statin-induced adverse effects such as myopathy. Grapefruit juice inhibits cytochrome P450 3A4, which is involved in simvastatin's metabolism."
Source: Clinical Pharmacy and Therapeutics, 4th ed. by Roger Walker and Cate Whittlesea, p.40.
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